abstract：OBJECTIVE:Extracellular inorganic pyrophosphate (ePPi) plays a key role in the regulation of normal and pathologic mineralization. The purpose of this work was to evaluate the role of P1 and P2 purine receptors in modulating ePPi production by articular chondrocytes. METHODS:Porcine cartilage explants and chondrocyte ...

journal_title：Osteoarthritis and cartilage

authors： Rosenthal AK,Hempel D,Kurup IV,Masuda I,Ryan LM

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between dynamic mechanical loading, as indicated by external knee adduction moment (KAM) measures during walking, and measures of articular cartilage morphology and subchondral bone size in people with medial knee osteoarthritis (OA). DESIGN:180 individuals with radiographic medi...

journal_title：Osteoarthritis and cartilage

authors： Creaby MW,Wang Y,Bennell KL,Hinman RS,Metcalf BR,Bowles KA,Cicuttini FM

更新日期：2010-11-01 00:00:00

abstract：:Animal model systems represent an important adjunct and surrogate for studies of osteoarthritis (OA) in humans. They provide a means to study OA pathophysiology as well as aid in the development of therapeutic agents and biological markers for diagnosing and prognosing the disease. Thus, it is of great importance for ...

journal_title：Osteoarthritis and cartilage

authors： Aigner T,Cook JL,Gerwin N,Glasson SS,Laverty S,Little CB,McIlwraith W,Kraus VB

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels,...

journal_title：Osteoarthritis and cartilage

authors： Vos PA,DeGroot J,Huisman AM,Oostveen JC,Marijnissen AC,Bijlsma JW,van El B,Zuurmond AM,Lafeber FP

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Increased pro-inflammatory cytokines and reactive oxygen and nitrogen species (RONS) occur in osteoarthritis (OA). Oxygen tension can alter the levels of RONS induced by interleukin-1 (IL-1). RONS such as nitric oxide (NO) can alter energy metabolism. The aim of this study was to determine if oxygen tension a...

journal_title：Osteoarthritis and cartilage

authors： Fermor B,Gurumurthy A,Diekman BO

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the association of T2 relaxation times of the knee with early degenerative cartilage changes. Furthermore the impact of unloading the knee on T2 values was evaluated. METHODS:Forty-three patients with knee pain and an ICRS (International Cartilage Repair Society) carti...

journal_title：Osteoarthritis and cartilage

authors： Apprich S,Welsch GH,Mamisch TC,Szomolanyi P,Mayerhoefer M,Pinker K,Trattnig S

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To determine if behavioral graded activity (BGA) results in better long-term effectiveness (5 years after inclusion) than usual exercise therapy (UC; usual care) in patients with osteoarthritis (OA) of the hip or knee. METHOD:Long-term follow-up study of a single blind cluster randomized trial comparing BGA ...

journal_title：Osteoarthritis and cartilage

authors： Pisters MF,Veenhof C,Schellevis FG,De Bakker DH,Dekker J

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:We investigated whether innate differences in cytokine response were associated with the absence of osteoarthritis (OA) in old age. DESIGN:In 82 participants from a cross-sectional birth cohort, radiographs of hands, hips and knees were taken at the age of 90 years. OA was defined as a Kellgren-Lawrence scor...

journal_title：Osteoarthritis and cartilage

authors： Goekoop RJ,Kloppenburg M,Kroon HM,Frölich M,Huizinga TW,Westendorp RG,Gussekloo J

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE AND METHODS:To evaluate the immune-modulator effect of chondroitin sulfate (CS) by means of the review of the literature. RESULTS:Inflammatory reactions are primarily originated by infectious agents, immune reactions and by sterile tissue lesions that activate membrane receptors by means of pathogen-associat...

journal_title：Osteoarthritis and cartilage

authors： Vallières M,du Souich P

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:The relative differences in effectiveness of subchondral stimulation, osteochondral grafts, and autologous chondrocyte implantation (ACI) are still unclear. It is the objective of this study to systematically review the literature on ACI compared to other treatments by clinical outcome and the quality of the ...

journal_title：Osteoarthritis and cartilage

authors： Vavken P,Samartzis D

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To evaluate differences in tibial trabecular bone (TB) texture between subjects with and without radiographic knee osteoarthritis (OA) using a variance orientation transform (VOT) method. DESIGN:Subjects with knee OA (Kellgren & Lawrence grade > or =2) and controls without OA (both n=26, seven women) were ma...

journal_title：Osteoarthritis and cartilage

authors： Wolski M,Podsiadlo P,Stachowiak GW,Lohmander LS,Englund M

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Investigate whether body mass index (BMI), comorbidity, gender and age predict patient-reported functional limitation 2- and 5-years after primary Total Knee Arthroplasty (TKA). METHODS:Overall moderate-severe activity limitation was defined as > or = 2 activities (walking, stairs, rising from chair) with mo...

journal_title：Osteoarthritis and cartilage

authors： Singh JA,O'Byrne M,Harmsen S,Lewallen D

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31 January 2006 to 31 January 2009. METHODS:A systematic literature search was undertaken using MEDLINE, EMBASE, CINAHL, AMED, Science Citation Index and t...

journal_title：Osteoarthritis and cartilage

authors： Zhang W,Nuki G,Moskowitz RW,Abramson S,Altman RD,Arden NK,Bierma-Zeinstra S,Brandt KD,Croft P,Doherty M,Dougados M,Hochberg M,Hunter DJ,Kwoh K,Lohmander LS,Tugwell P

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Implantation of autologous chondrocytes (AC) is a promising option for the treatment of cartilage defects, but problems with cell harvesting, dedifferentiation, or the donor age limit the clinical outcome. Mesenchymal stem cells (MSC) gain much interest because of their simple isolation and multipotential dif...

journal_title：Osteoarthritis and cartilage

authors： Akay I,Oxmann D,Helfenstein A,Mentlein R,Schünke M,Hassenpflug J,Kurz B

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The purpose of the current study was to investigate the feasibility of applying defect-size femoral implants for the treatment of localized cartilage defects in a 1-year follow-up model. METHODS:In 13 goats, a medial femoral condyle defect was created in both knees. Defects were randomly treated by immediate...

journal_title：Osteoarthritis and cartilage

authors： Custers RJ,Dhert WJ,Saris DB,Verbout AJ,van Rijen MH,Mastbergen SC,Lafeber FP,Creemers LB

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to develop an algorithm to semi-automatically segment the meniscus in a series of magnetic resonance (MR) images to use for normal knees and those with moderate osteoarthritis (OA). METHOD:The segmentation method was developed then evaluated on 10 baseline MR images obtained from s...

journal_title：Osteoarthritis and cartilage

authors： Swanson MS,Prescott JW,Best TM,Powell K,Jackson RD,Haq F,Gurcan MN

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:A significant risk factor for anterior cruciate ligament (ACL) tears in young athletes is a reduced femoral Notch Width Index (NWI). The purpose of this study was to test if persons with knee osteoarthritis (OA) and ACL tears have smaller NWI independent of prior joint injury and osteophyte volume. METHODS:W...

journal_title：Osteoarthritis and cartilage

authors： Stein V,Li L,Guermazi A,Zhang Y,Kent Kwoh C,Eaton CB,Hunter DJ,OAI Investigators.

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties. This article aims to provide a summary of the actions of curcumin on articular chondrocytes from the available literatu...

journal_title：Osteoarthritis and cartilage

authors： Henrotin Y,Clutterbuck AL,Allaway D,Lodwig EM,Harris P,Mathy-Hartert M,Shakibaei M,Mobasheri A

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To date semiquantitative whole-organ scoring of knee osteoarthritis (OA) relies on 1.5 Tesla (T) Magnetic resonance imaging (MRI) systems. Less costly 1.0 T extremity systems have been introduced that offer superior patient comfort, but may have limitations concerning field-of-view and image quality. The aim ...

journal_title：Osteoarthritis and cartilage

authors： Roemer FW,Lynch JA,Niu J,Zhang Y,Crema MD,Tolstykh I,El-Khoury GY,Felson DT,Lewis CE,Nevitt MC,Guermazi A

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the feasibility of quantifying the Equilibrium Partitioning of an Ionic Contrast agent via Microcomputed Tomography (EPIC-microCT) to nondestructively assess sulfated glycosaminoglycan (sGAG) content and distribution in rat articular cartilage ex vivo, and in doing ...

journal_title：Osteoarthritis and cartilage

authors： Xie L,Lin AS,Guldberg RE,Levenston ME

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Oral glucosamine (GlcN) has been widely studied for its potential therapeutic benefits in alleviating the pain and disability of osteoarthritis (OA). Its popularity has grown despite ongoing controversy regarding its effectiveness vs placebo in clinical trials, and lack of information regarding possible mecha...

journal_title：Osteoarthritis and cartilage

authors： Block JA,Oegema TR,Sandy JD,Plaas A

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Subchondral bone attrition (SBA) is defined as flattening or depression of the osseous articular surface. The causes of attrition are unknown, but remodeling processes due to chronic overload that are reflected as bone marrow edema-like lesions (BMLs) on magnetic resonance imaging (MRI) might predispose the s...

journal_title：Osteoarthritis and cartilage

authors： Roemer FW,Neogi T,Nevitt MC,Felson DT,Zhu Y,Zhang Y,Lynch JA,Javaid MK,Crema MD,Torner J,Lewis CE,Guermazi A

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the psychometric properties of the French KOOS physical function (KOOS-PS) and HOOS physical function (HOOS-PS), specifically its feasibility, reliability, construct validity, and responsiveness. METHODS:Consecutive outpatients consulting for primary knee or hip osteoarthritis (OA) in a rheumatol...

journal_title：Osteoarthritis and cartilage

authors： Ornetti P,Perruccio AV,Roos EM,Lohmander LS,Davis AM,Maillefert JF

更新日期：2009-12-01 00:00:00

abstract：:The human masticatory system consists of a mandible which is able to move with respect to the skull at its bilateral temporomandibular joint (TMJ) through contractions of the masticatory muscles. Like other synovial joints, the TMJ is loaded mechanically during function. The articular surface of the mandibular condyle...

journal_title：Osteoarthritis and cartilage

authors： Kuroda S,Tanimoto K,Izawa T,Fujihara S,Koolstra JH,Tanaka E

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Patterns of radiographic osteoarthritis (ROA) of the hand are often examined by row, with the four joints of the thumb studied inconsistently. The objectives of this study were to determine relationships of ROA at different hand joints, use the findings to define radiographic sub-groups and investigate their ...

journal_title：Osteoarthritis and cartilage

authors： Marshall M,van der Windt D,Nicholls E,Myers H,Hay E,Dziedzic K

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:To examine whether categories of anatomic alignment (varus, neutral, valgus) measured from knee X-rays agree with similar categories of mechanical alignment from the full limb film and whether varus anatomic malalignment predicts medial joint space loss on knee X-rays as well as varus mechanical alignment. ...

journal_title：Osteoarthritis and cartilage

authors： Felson DT,Cooke TD,Niu J,Goggins J,Choi J,Yu J,Nevitt MC,OAI Investigators Group.

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To update our earlier systematic review which evaluated all published randomized controlled trials (RCTs) evaluating pharmacological and non-pharmacological therapies in patients with hand osteoarthritis (OA). Surgical therapies were not evaluated. METHOD:RCTs published between August 2004 and February 2008 ...

journal_title：Osteoarthritis and cartilage

authors： Mahendira D,Towheed TE

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:This study examined within-day osteoarthritis (OA)-related pain patterns and associated patient characteristics. METHODS:Participants with physician diagnoses and self-reported symptoms of hand (N=40), hip (N=32), and knee (N=85) OA recorded pain using a handheld computer on one weekday and one weekend day, ...

journal_title：Osteoarthritis and cartilage

authors： Allen KD,Coffman CJ,Golightly YM,Stechuchak KM,Keefe FJ

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To test the efficacy of phase-sensitive X-ray imaging for intact synovial joints, whereby refraction effects, along with the attenuation of conventional radiography, can be exploited. DESIGN:Intact cadaveric human knee joints were imaged, in the computed tomographic mode, using an analyzer-based X-ray system...

journal_title：Osteoarthritis and cartilage

authors： Li J,Zhong Z,Connor D,Mollenhauer J,Muehleman C

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of waiting time on health and quality of life outcomes and costs of medication in total hip replacement (THR) patients in a randomized clinical trial. METHODS:395 THR patients were recruited into the study. When placed on the waiting list, patients were randomized into a short (< or =3...

journal_title：Osteoarthritis and cartilage

authors： Tuominen U,Sintonen H,Hirvonen J,Seitsalo S,Paavolainen P,Lehto M,Hietaniemi K,Blom M

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Here we investigate whether monolayer culture or culture at 21% oxygen influences activity of cytochrome c oxidase, the terminal enzyme in the respiratory chain whose activity is essential for oxidative metabolism and whether return to three dimensional (3-D) culture restores cytochrome c oxidase activity to ...

journal_title：Osteoarthritis and cartilage

authors： Boubriak OA,Brooks JT,Urban JP

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Although SOX9 is a key molecule for chondrogenic differentiation, little is known about the upstream signal. The present study attempted to identify transcription factors to induce SOX9 expression and examined the mechanism. METHODS:Sequences of about 1 kb of 5'-end flanking regions were compared between hum...

journal_title：Osteoarthritis and cartilage

authors： Ushita M,Saito T,Ikeda T,Yano F,Higashikawa A,Ogata N,Chung U,Nakamura K,Kawaguchi H

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to characterize mouse temporomandibular joint (TMJ) following partial discectomy, since there is no documentation of whether or not partial discectomy can induce early-onset osteoarthritis (OA) in mouse TMJ. METHODS:Partial discs of TMJ in mice were removed by microsurgery. His...

journal_title：Osteoarthritis and cartilage

authors： Xu L,Polur I,Lim C,Servais JM,Dobeck J,Li Y,Olsen BR

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS:Body mass index (BMI) was calculated in 45 patients (16 women),...

journal_title：Osteoarthritis and cartilage

authors： Ericsson YB,Tjörnstrand J,Tiderius CJ,Dahlberg LE

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:This cross-sectional study examined the association of limb length inequality (LLI) with chronic joint symptoms at the hip and knee in a large, community-based sample, adjusting for the presence of radiographic osteoarthritis (OA) and other confounders. METHODS:The total study group comprised 3012 participan...

journal_title：Osteoarthritis and cartilage

authors： Golightly YM,Allen KD,Helmick CG,Renner JB,Jordan JM

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Both animal and human studies using magnetic resonance imaging (MRI) show that cartilage degeneration increases the T2 value. However, it is unclear whether the T2 value correlates linearly with water content in cartilage with osteoarthritis. The purpose of this study was to investigate the relationship betwe...

journal_title：Osteoarthritis and cartilage

authors： Chou MC,Tsai PH,Huang GS,Lee HS,Lee CH,Lin MH,Lin CY,Chung HW

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Recently we reported that glucosamine sulphate (GS) did not have an effect on the symptoms and progression of primary care patients with hip osteoarthritis (OA). The aim of this present study was to investigate whether there are subgroups of patients with hip OA for whom GS might be an effective therapy. MET...

journal_title：Osteoarthritis and cartilage

authors： Rozendaal RM,Uitterlinden EJ,van Osch GJ,Garling EH,Willemsen SP,Ginai AZ,Verhaar JA,Weinans H,Koes BW,Bierma-Zeinstra SM

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Outcome in osteochondral allografting is limited by the immunological incompatibility of the grafted tissue. Based on a resistance of chondrocytes to photodynamic therapy in cell culture it is proposed that 5-aminolevulinic acid-based photodynamic therapy (5-ALA-PDT) might be used to inactivate bone while mai...

journal_title：Osteoarthritis and cartilage

authors： Bastian JD,Egli RJ,Ganz R,Hofstetter W,Leunig M

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:An age-related decline in chondrocyte production of osteogenic protein-1 (OP-1) (Bone Morphogenetic Protein-7) may contribute to cartilage loss in osteoarthritis. This study was designed to determine if increased methylation of the OP-1 promoter might serve as a mechanism for the age-related decline in OP-1 e...

journal_title：Osteoarthritis and cartilage

authors： Loeser RF,Im HJ,Richardson B,Lu Q,Chubinskaya S

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Characterize the effects of alendronate (ALN) on the repair process of the osteonecrotic femoral head as well as the development of secondary osteoarthritis in the ipsilateral hip in an established experimental model of osteonecrosis. METHODS:Osteonecrosis of the femoral head was induced surgically in 60 adu...

journal_title：Osteoarthritis and cartilage

authors： Hofstaetter JG,Wang J,Yan J,Glimcher MJ

更新日期：2009-03-01 00:00:00